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S. Liu, T. Chai, F. Garcia-Marques, Q. Yin, E-C. Hsu, M. Shen, A. Toland, A. Bermudez, A. Hartono, C. Massey, C. Lee, L, Zheng, M. Baron, C. Denning, M. Aslan, H. Nguyen, R. Nolley, A. Zoubeidi, M. Das, C. Kunder, B. Howitt, H. T. Soh, I. Weissman, M. Liss, A. Chin, J. Brooks, E. Corey, S. Pitteri, J. Huang, T. Stoyanova. "UCHL is a potential molecular indicator and therapeutic target for neuroendocrine carcinomas."  Cell Reports Medicine (2024) .pdf

M. Chorsi, W. Linthicum, A. Pozhidaeva, C. Mundrane, V. Mulligan, Y. Chen, P. Tavousi, V. Gorbatyuk, O. Vinogradova, J. Hoch, B. Huey, T. Nguyen, H.T. Soh, K. Kazerounian, H. Ilies.  "Ultra-confined controllable cyclic peptides as supramolecular biomaterials."  Nano Today (2024) .pdf

D. Kong, I. Thompson, N. Maganzini, M. Eisenstein, H.T. Soh.  “Aptamer-antibody chimera sensors for sensitive, rapid and reversible molecular detection in complex samples.”  ACS Sensors (2024)  .pdf

K.S. Park, H. Cha, J. Niu, H.T. Soh, J.H. Lee, S.P Pack.  "DNA-controlled Protein Fluorescence: Design of aptamer-split peptide hetero-modulator for GFP to respond to intracellular ATP level."  Nucleic Acids Research (2024)

J. Chien, Y. Tsai, S. Baker, K. Gates, A. Arbabian, H.T. Soh.  "Wireless Monitoring of Small Molecules in a Freely Moving Animal using Electrochemical Aptamer Biosensors." (Submitted)

N. Maganzini, A. Reschke, A. Cartwright, Y. Gidi, I. Thompson, A. Hariri, C. Dory, Y. Rosenberg-Hasson, J. Pan, M. Eisenstein, T. Cornell, H.T. Soh.  "A rapid ELISA platform with no sample preparation requirement.bioRxiv  .pdf

N. Vitale, A. Hassibi, H.T. Soh, B. Murmann, T.H. Lee.  "Inherent Stochasticity, Noise, and Limits of Detection in Continuous and Time-gated Fluorescence Systems." (Submitted)

S. Newman. L. Hein, A. Adams, H.T. Soh. "Theoretical framework and experimental validation of multiplexed analyte quantification using cross-reactive affinity reagents." bioRxiv  .pdf

H. Zhen, A.M. Rao, A. Ganesan, H.T. Soh, B.A.J. Ponder, R.C. Rintoul, P. Khatri.  "Multi-cohort analysis identifies a blood-based host immune transcriptomic signature for early lung cancer detection."  (Submitted)

S. Newman, B. Wilson, L. Zheng, M. Eisenstein, H.T. Soh.  "A multiplexed and quantitative assay for small-molecule detection via photo-crosslinking of structure switching aptamers."  bioRxiv  .pdf

L. Zheng, Y. Sun, M, Eisenstein, H.T. Soh. "Peptide sequencing via reverse translation of peptides into DNA."  bioRxiv  .pdf


M. Friedel, I. Thompson, G. Kasting, R. Polsky, D. Cunningham, H.T. Soh, J. Heikenfeld.  "Opportunities and challenges in the diagnostic utility of dermal interstitial fluid." Nature Biomedical Engineering (2023) .pdf

I. Thompson, J. Saunders, L. Zheng, A. Hariri, N. Maganzini, A. Cartwright, J. Pan, M. Eisenstein, H.T. Soh.  "An antibody-based molecular switch for continuous small-molecule biosensing.Science Advances (2023) .pdf

A. Yoshikawa, A. Rangel, L. Zheng, L. Wan, L. Hein, A. Hariri, M. Eisenstein, H.T. Soh.  "A massively parallel screening platform for converting aptamers into molecular switches." Nature Communications (2023) .pdf

S. Newman, B. Wilson, D. Mamerow, B. Wollant, H. Nyein, Y. Rosenberg-Hasson, H. Maecker, M. Eisenstein, H.T. Soh.  "Extending the dynamic range of biomarker quantification through molecular equalization."  Accepted, Nature Communications (2023) .pdf

A. Hariri, A. Cartwright, C. Dory, Y. Gidi, S. Yee, K. Fu, K. Yang, D. Wu, I. Thompson, N. Maganzini, T. Feagin, B. Young, B. Afshar, M. Eisenstein, M. Digonnet, J. Vuckovic, H.T. Soh.  "Modular Aptamer Switches for the Continuous Optical Detection of Small-Molecule Analytes in Complex Media."  Advanced Materials (2023) .pdf

C. Park, I. Thompson, S. Newman, L. Hein, X. Lian, K. Fu, J. Pan, M. Eisenstein, H.T. Soh.  "Real-Time Spatiotemporal Measurement of Extracellular Signaling Molecules Using an Aptamer Switch-Conjugated Hydrogel Matrix."  Advanced Materials (2023) .pdf

H. Qu, M. Zheng, Q. Ma, L. Wang, Y. Mao, M. Eisenstein, H.T. Soh, L. Zheng.  "Allosteric Regulation of Aptamer Affinity through Mechano-Chemical Coupling.Angew. Chemie. Int’l Ed (2023) .pdf

A. Alvarez-Buylla, M. Moya-Garzon, A. Rangel, E. Tapia, J. Tanzo, H.T. Soh, L. Coloma, J. Long, L. O'Connell.  "Binding and sequestration of poison frog alkaloids by a plasma globulin.eLife (2023) .pdf

L. Wan, A. Yoshikawa, M. Eisenstein, H.T. Soh.  "A high-throughput strategy for enhancing aptamer performance across different environmental conditions.ACS Sensors (2023) .pdf

K. Park, A. Choi, H. Kim, I. Park, M. Eom, S. Yeo, R. Son, T. Park, G. Lee, H.T. Soh, Y. Hong, S. Pak.  "Ultra-sensitive label-free SERS biosensor with high-throughput screened DNA aptamer for universal detection of SARS-CoV-2 variants from clinical samples."  Biosensors and Bioelectronics (2023) .pdf (part 1) .pdf (part 2)

D. Wu, T. Feagin, P. Mage, A. Rangel, L. Wan, A. Li, J. Coller, M. Eisenstein, S. Pitteri, H. T. Soh.  “Flow-Cell-Based Technology for Massively Parallel Characterization of Base-Modified DNA Aptamers.Analytical Chemistry (2023) .pdf


A. Yoshikawa, L. Wan, L. Zheng, M. Eisenstein, H. T. Soh. "A system for multiplexed selection of aptamers with exquisite specificity without counter-selection." Proceedings of the National Academy of Sciences  (2022) .pdf

D. Chan, J. Chien, E. Axpe, L. Blankemeier, S. W. Baker, S. Swaminathan, V. A. Piunova, D. Y. Zubarev, H. T. Soh, E. A. Appel. “Combinatorial Polyacrylamide Hydrogels for Preventing Biofouling on Implantable Biosensors.”  Advanced Materials (Accepted, 2022) .pdf

A. Hariri, S. Newman, S. Tan, D. Mamerow, M. Eisenstein, A. Dunn, H.T. Soh. "Improved immunoassay sensitivity and specificity using single-molecule colocalization." Nature Communications (2022) .pdf

N. Maganzini, I. Thompson, B.D. Wilson, H.T. Soh. "Pre-equilibrium biosensors: A new approach towards rapid and continuous molecular measurements." Nature Communications (2022) .pdf 

D. Wu, C. Gordon, J. Shin, M. Eisenstein, H. T. Soh. "Directed Evolution of Aptamer Discovery Technologies." Accounts of Chemical Research (2022) .pdf

T. Trinh, I. Thompson, F. Clark, J. Remington, M. Eisenstein, J. Li, H.T. Soh.  "A Photoresponsive Intramolecular Triplex Motif That Enables Rapid and Reversible Control of Aptamer Binding Activity.ACS Nano (2022) .pdf

J. Wang, F. Soto, P. Ma, R. Ahmed, H. Yang, S. Chen, J. Wang, C. Liu, D. Akin, K. Fu, P. Chen, H.T. Soh, J. Wu, U. Demirci.  "Acoustic Fabrication of Living Cardiomyocyte-based Hybrid Biorobots.ACS Nano (2022) .pdf

V. Kesler, K. Fu, Y. Chen, C. Park, M. Eisenstein, B. Murmann, H.T. Soh. "Tailoring electrode surface charge to achieve discrimination and quantification of chemically similar small molecules with electrochemical aptamers." Advanced Functional Materials (2022) .pdf


B. D. Wilson, M. Eisenstein, H. T. Soh.  "A Metric for Quantifying the Resolution of Molecular Assays."  Nature Biomedical Engineering (2021)  .pdf

J. W. Seo, K. Fu, S. Correa, M. Eisenstein, E. A. Appel, H. T. Soh.  "Real-time monitoring of drug pharmacokinetics within tumor tissue in live animals."  Science Advances (2021) .pdf

A. Yoshikawa, A. Rangel, T. Feagin, E. Chun, L. Wan, A. Li, L. Moekl, M. Eisenstein, S. Pitteri, H. T. Soh.  Discovery of indole-modified aptamers for highly specific recognition of protein glycoforms.”  Nature Communications (2021) .pdf

K. Fu, J. W. Seo, V. Kesler, N. Maganzini, B. D. Wilson, M. Eisenstein, H. T. Soh.  “Accelerated electron transfer in nanostructured electrodes improves the sensitivity of electrochemical biosensors.”  Advanced Science (2021) .pdf

H. Lee, S. Sohn, S. Alizadeh, S. Kwon. T. Kim, S. Park, H. T. Soh, A. Mani, S J Kim.  "Overlimiting Current in Nonuniform Arrays of Microchannels: Recirculating Flow and Anticrystallization.” Nano Letters (2021) .pdf


M. Poudineh, C. L. Maikawa, E. Y. Ma, J. Pan, D. Mamerow, Y. Han, S. W. Baker, A. Beirami, M. Eisenstein, S. Kim, J. Vuckovic, E. A. Appel, H. T. Soh.  “Continuous detection of glucose and insulin in live animals.”  Nature Biomedical Engineering (2020)

I. A. P. Thompson, L. Zheng, M. Eisenstein, H. T. Soh.  “Rational Design of Aptamer Switches with Programmable pH Response.”  Nature Communications 11, 2946 (2020) .pdf

A. Rangel, A. Hariri, M. Eisenstein, H. T. Soh.  “Engineering aptamer switches for multifunctional stimulus-responsive nanosystems.”  Advanced Materials (2020)

V. Kesler, B. Murmann, H. T. Soh.  “Going Beyond the Debye Length: Overcoming Charge Screening Limitations in Next-Generation Bioelectronic Sensors.”  ACS Nano (2020) .pdf

H. Qu, Q. Ma, L. Wang, Y. Mao, M. Eisenstein, H. T. Soh*, L. Zheng*.  “Measuring aptamer folding energy using a molecular clamp.”  Journal of the American Chemical Society 142, 27, 11743–11749 (2020) .pdf

B. D. Wilson, H. T. Soh.  “Re-evaluating the conventional wisdom about binding assays.”  Trends in Biochemical Sciences 45 (8) 639-649 (2020) .pdf

J. Wang, R. Ahmed, Y. Zeng, K. Fu, H.T. Soh, U. Demirci.  “Nano-topographically engineered multifunctional immunocyte-templated micromotors.”  Small (2020)

J. Chien, S. W. Baker, H. T. Soh, A. Arabian.  “Design and Analysis of a Sample-and-Hold CMOS Electrochemical Sensor for Aptamer-based Therapeutic Drug Monitoring.”  IEEE Journal of Solid-State Circuits (2020) .pdf

Aptamer Selection

Click-Particle Display for Base-Modified Aptamer Discovery

C. K. L. Gordon*, D. Wu*, A. Pusuluri, T. Feagin, A. T. Csordas, M. Eisenstein, C. J. Hawker, J. Niu, H. T. Soh.  “Click-Particle Display for Base-Modified Aptamer Discovery.”  ACS Chemical Biology 14 (12) 2652-2662 (2019)


P. L. Mage, A. T. Csordas, T. Brown, D. Klinger, M. Eise, S. Mitragotri, C. J. Hawker and H. T. Soh.  “Shape-based Separation of Synthetic Microparticles.”  Nature Materials 18, 82-89 (2019) 

B. Wilson, A. Hariri, I. Thompson, M. Eisenstein, H. T. Soh.  “Independent Control of the Thermodynamic and Kinetic Properties of Aptamer Switches.”  Nature Communications 10, 5079 (2019) 

C. K. L. Gordon*, D. Wu*, A. Pusuluri, T. Feagin, A. T. Csordas, M. Eisenstein, C. J. Hawker, J. Niu, H. T. Soh.  “Click-Particle Display for Base-Modified Aptamer Discovery.”  ACS Chemical Biology 14 (12) 2652-2662 (2019)

B. Wilson, M. Eisenstein, H. T. Soh.  “High-Fidelity Nanopore Sequencing of Ultra-Short DNA Targets.”  Analytical Chemistry 91 (10) 6783-6789 (2019) 

B. Kang, S. V. Park, H. T. Soh, S. S. Oh.  “A Dual-sensing DNA Nanostructure with an Ultra-broad Detection Range.”  ACS Sensors 4 (10) 2802-2808 (2019)

Real-Time Biosensing

Closed-Loop Control of Circulating Drug Levels in Live Animals

P. L. Mage, B. S. Ferguson, D. Maliniak, K. L. Ploense, T. E. Kippin, and H. T. Soh.  “Closed-Loop Control of Circulating Drug Levels in Live Animals.”  Nature Biomedical Engineering (2017) DOI: 10.1038/s41551-017-0070

Aptamer Selection

Multi-Parameter Particle Display (MPPD): A Quantitative Screening Method for Discovery of Highly Specific Aptamers

J.P Wang, J. McDermott, J. Yu, R. Lagrois, Q. Gong, W. Greenleaf, M. Eisenstein, B.S. Ferguson, and H.T. Soh.  “Multi-Parameter Particle Display (MPPD): A Quantitative Screening Method for Discovery of Highly Specific Aptamers.”  Angewandte Chemie International Edition 56 (3) 744-747 (2017)  DOI: 10.1002/anie.201608880


Barnes, L. V, D.M. Heithoff, S.P. Mahan, G.N. Fox, A. Zambrano, J. Choe, L.N. Fitzgibbons, J.D. Marth, J.C. Fried, H.T. Soh*, M.J. Mahan*.  “Smartphone-based pathogen diagnosis in urinary sepsis patients.”  EbioMedicine 36, 73-82 (2018)

M. Gotrik, G. Sekhon, S. Saurabh, M. Nakamoto, M. Eisenstein, H. T. Soh.  “Direct Selection of Fluorescence-Enhancing RNA Aptamers.”  Journal of the American Chemical Society 140 (10) 3583-3591 (2018)

A. Pusuluri, V. Krishnan, V. Lensch, A. Sarode, E. Bunyan, D. Vogus, S. Menegatti, H. T. Soh*, S. Mitragotri*.  “Treating Tumors at Low Drug Doses Using an Aptamer-Peptide Synergistic Drug Conjugate.”  Angewandte Chemie International Edition 58 (5) 1437-1441 (2018)

J. McGivney, A. Csordas, F. Walker, E. Bagley, E.Gruber, P. Mage, J. Casas-Finet, M. Nakamoto, M. Eisenstein, C. Larkin, R. Strouse, H. T. Soh.  “A Strategy for Generating Sequence-Defined Aptamer Reagent Sets for Detecting Protein Contaminants in Biotherapeutics.”  Analytical Chemistry 90 (5) 3262-3269 (2018)

T. Feagin, N. Maganzini, H.T. Soh.  “Strategies for Creating Structure-Switching Aptamers.”  ACS Sensors 3 (9), 1611-1615 (2018)

C. K. L. Gordon, M. Eisenstein, H. Tom Soh.  “Direct Selection Strategy for Isolating Aptamers with pH-Sensitive Binding Activity.”  ACS Sensors 3 (12) 2574-2580 (2018)


P. L. Mage, B. S. Ferguson, D. Maliniak, K. L. Ploense, T. E. Kippin, and H. T. Soh.  “Closed-Loop Control of Circulating Drug Levels in Live Animals.”  Nature Biomedical Engineering (2017) DOI: 10.1038/s41551-017-0070

J. Niu, D. Lunn, A. Pusuluri, J. Yoo, M. O’Malley, S. Mitragotri, H.T. Soh, and C.J. Hawker.  “Engineering live cell surfaces with functional polymers via cytocompatible controlled radical polymerization.”  Nature Chemistry 9, 537-545 (2017)  DOI: 10.1038/nchem.2713

T. Chuong, A. Pallaoro, C. Chaves, Z. Li, J. Lee, M. Eisenstein, G.D. Stucky, M. Moskovits, and H. T. Soh.  “A dual-reporter SERS-based biomolecular assay with reduced false-positive signals.”  Proceedings of the National Academy of Sciences (2017) DOI: 10.1073/pnas.1700317114

J.P Wang, J. McDermott, J. Yu, R. Lagrois, Q. Gong, W. Greenleaf, M. Eisenstein, B.S. Ferguson, and H.T. Soh.  “Multi-Parameter Particle Display (MPPD): A Quantitative Screening Method for Discovery of Highly Specific Aptamers.”  Angewandte Chemie International Edition 56 (3) 744-747 (2017)  DOI: 10.1002/anie.201608880

J. Niu, Z.A. Page, N.D. Dolinski, A. Anastasaki, A.T. Hsueh, H.T. Soh, and C.J. Hawker.  “Rapid Visible Light-Mediated Controlled Aqueous Polymerization with In Situ Monitoring.”  ACS Macro Letters (2017)DOI: 10.1021/acsmacrolett.7b00587


M. Gotrik, T. Feagin, A.T. Csordas, M. Nakamoto, and H.T. Soh.  “Advancements in Aptamer Discovery Technologies.”  Accounts of Chemical Research 49 (9) 1903-1910 (2016)  DOI: 10.1021/acs.accounts.6b00283 

F. Fong, S-S Oh, J.C. Hawker, and H.T. Soh.  “In vitro selection of pH-activated DNA nanostructures.”  Angewandte Chemie International Edition 55 (49) 15258-15262 (2016)  DOI: 10.1002/anie.201607540

H. Qu, A.T. Csordas, J.P. Wang, S-S Oh, M. Eisenstein, and H.T. Soh.  “Rapid and label-free strategy to select aptamers for metal ions.” ACS Nano 10 (8) 7558-7565 (2016)  DOI: 10.1021/acsnano.6b02558

A. Csordas, A. Jorgensen, J.P. Wang, E. Gruber, Q. Gong, E. Bagley, M. Nakamoto, M. Eisenstein, and H.T. Soh.  “High-throughput discovery of aptamers for sandwich assays.”  Analytical Chemistry 88 (22) 10842-10847 (2016)  DOI: 10.1021/acs.analchem.6b03450

S. O. Poelma, S-S Oh, S. Helmy, H. T. Soh, C. J. Hawker, and J. Read de Alaniz.  “Controlled Drug Release to Cancer Cells from Modular One-Photon Visible Light-Responsive Micellar System.”  Chemical Communications 52 (69) 10525-10528 (2016)  DOI: 10.1039/C6CC04127B


M. Cho, S-S. Oh, J. Nie, R. Stewart, M. Radeke, M. Eisenstein, P. Coffey, J. Thomson, and H.T. Soh.  “Array-Based Discovery of Aptamer Pairs.”  Analytical Chemistry 87 (1) 821-828 (2015)  DOI: 10.1021/ac504076k

K. Hsieh, B.S. Ferguson, M. Eisenstein, K.W. Plaxco, and H.T. Soh.  “Integrated electrochemical microsystems for genetic detection of pathogens at the point of care.”  Accounts of Chemical Research 48 (4) 911-920 (2015)  DOI: 10.1021/ar500456w

O. Jakobsson, S-S. Oh, M. Antfolk, M. Eisenstein, T. Laurell, and H.T. Soh.  “Thousand-fold volumetric concentration of live cells with a recirculating acoustofluidic device.”  Analytical Chemistry 87 (16) 8497-8502 (2015) DOI: 10.1021/acs.analchem.5b01944


K. Hsieh, P.L. Mage, A.T. Csordas, M.S. Eisenstein, and H.T. Soh.  “Simultaneous Elimination of Carryover Contamination and Detection of DNA with Uracil-DNA-Glycosylase-Supplemented Loop-Mediated Isothermal Amplification (UDG-LAMP).”  Chemical Communications 50 (28) 3747-3749 (2014)  DOI: 10.1039/C4CC00540F

J.P. Wang, Q. Gong, N. Maheshwari, M. Eisenstein, M.L. Arcila, K.S. Kosik, and H.T. Soh.  “Particle Display: A Quantitative Screening Method for Generating High-Affinity Aptamers.”  Angewandte Chemie International Edition 53 (19) 4796-4801 (2014)  DOI: 10.1002/anie.201309334

A.H.J. Yang, K. Hsieh, A.S. Patterson, B.S. Ferguson, M. Eisenstein, K.W. Plaxco, and H.T. Soh.  “Accurate Zygote-Specific SNP Discrimination Using Microfluidic Electrochemical DNA Melt Curves.”  Angewandte Chemie International Edition 53 (12) 3163-3167 (2014) DOI: 10.1002/anie.201310059

K.S. Park, S-S. Oh, H.T. Soh, and H.G Park.  “Target-controlled formation of silver nanoclusters in abasic site-incorporated duplex DNA for label-free fluorescent detection of theophylline.”  Nanoscale 6 (17) 9977-9982 (2014)  DOI: 10.1039/C4NR00625A

P. Jiang, Z. Hou, N.E. Propson, H.T. Soh, J.A. Thomson, and R. Stewart.  “MPBind: A Meta-Motif Based Statistical Framework and Pipeline to Predict Binding Potential of SELEX-derived Aptamers.”  Bioinformatics 30 (18) 2265-2267 (2014)  DOI: 10.1093/bioinformatics/btu348

Y.K. Jung, M.A. Woo, H.T. Soh, and H.G. Park.  “Aptamer-Based Cell Imaging Reagents Capable of Fluorescence Switching.”  Chemical Communications 50 (82) 12329-12332 (2014)  DOI: 10.1039/C4CC03888F

F.M. Walker, K.M. Ahmad, M. Eisenstein, and H.T. Soh.  “Transformation of Personal Computers and Mobile Phones into Genetic Diagnostic Systems.”  Analytical Chemistry 86 (18) 9236-9241 (2014)  DOI: 10.1021/ac5022419

S-S. Oh, B. Lee, F. Leibfarth, M. Eisenstein, M. Robb, N. Lynd, C. Hawker, and H.T. Soh.  “Synthetic Aptamer-Polymer Hybrid Constructs for Programmed Drug Delivery into Specific Target Cells.”  Journal of the American Chemical Society 50 (82) 12329-12329 (2014)  DOI: 10.1021/ja5079464


S. Meyer, J.P. Maufort, J. Nie, R. Stewart, B. McIntosh, L. Conti, K.M. Ahmad, H.T. Soh, and J.A. Thomson.  “Development of an Efficient Targeted Cell-SELEX Procedure for DNA Aptamer Reagents.”  PLoS One 8 (8) e71798 (2013)  DOI: 10.1371/journal.pone.0071798

A. Patterson, D. Heithoff, B.S. Ferguson, H.T. Soh, M. Mahan, and K.W. Plaxco.  “Microfluidic Chip-based Detection and Intraspecies Strain Discrimination of Salmonella Serovars Derived from Whole Blood of Septic Mice.”  Applied and Environmental Microbiology 4 (7) 2302-2311 (2013)  DOI: 10.1128/AEM.03882-12

B.S. Ferguson, D.A. Hoggarth, D. Maliniak, K. Ploense, R.J. White, N. Woodward, K. Hsieh, A.J. Bonham, M. Eisenstein, T. Kippin, K.W. Plaxco, and H.T. Soh.  “Real-time, aptamer-based tracking of circulating therapeutic agents in living animals.”  Science Translational Medicine 5 (213) 213ra165 (2013)  DOI: 10.1126/scitranslmed.3007095

S-S. Oh, K. Plaxco, Y. Xiao, M. Eisenstein, and H.T. Soh.  “In Vitro Selection of Shape-Changing DNA Nanostructures Capable of Binding-Induced Cargo Release.”  ACS Nano 7 (11) 9675-9683 (2013)  DOI: 10.1021/nn404079v

A.S. Patterson, K. Hsieh, H.T. Soh, and K.W. Plaxco.  “Electrochemical Real-Time Nucleic Acid Amplification: Towards Point-of-Care Quantification of Pathogens.”  Trends in Biotechnology 31 (12) 704-712 (2013)  DOI: 10.1016/j.tibtech.2013.09.005

M. Cho, S-S. Oh, J. Nie, R. Stewart, M.S. Eisenstein, J. Chambers, J.D. Marth, F. Walker, J.A. Thomson, and H.T. Soh.  “Quantitative Selection and Parallel Characterization of Aptamers.”  Proceedings of the National Academy of Sciences 110 (46) 18460-18465 (2013)  DOI: 10.1073/pnas.1315866110


J.P. Wang, J.F. Rudzinski, Q. Gong, H.T. Soh, and P.J. Atzberger.  “Influence of Target Concentration and Background Binding on In Vitro Selection of Affinity Reagents.”  PLoS One 7 (8) e43940 (2012)  DOI: 10.1371/journal.pone.0043940

Q. Gong, J. Wang, K.M. Ahmad, A.T. Csordas, J. Zhou, J. Nie, R. Stewart, J. Thomson, J. Rossi, and H.T. Soh.  “Selection Strategy to Generate Aptamer Pairs that Bind to Distinct Sites on Protein Target.”  Analytical Chemistry 84 (12) 5365-5371 (2012)  DOI: 10.1021/ac300873p

J.D. Adams, C.L. Ebbesen, R. Barnkob, A.H.J. Yang, H.T. Soh, and H. Bruus.  “High-throughput, Temperature-controlled Microchannel Acoustophoresis Device made with Rapid Prototyping.”  Journal of Micromechanics and Microengineering 22 (075017) 1-8 (2012)  DOI: 10.1088/0960-1317/22/7/075017

A.H.J. Yang and H.T. Soh.  “Acoustophoretic Sorting of Viable Mammalian Cells in a Microfluidic Device.”  Analytical Chemistry 84 (24) 10756-10762 (2012)  DOI: 10.1021/ac3026674

A. Bonham, K. Hsieh, B. Ferguson, A. Vallée-Bélisle, F. Ricci, H.T. Soh, and K.W.Plaxco.  “Quantification of Transcription Factor Binding in Cell Extracts using an Electrochemical, Structure-switching Biosensor.”  Journal of the American Chemical Society 134 (7) 3346-3348 (2012)  DOI: 10.1021/ja2115663

S. Deborggraeve, J.Y. Dai, Y. Xiao, and H.T. Soh.  “Controlling the Function of DNA Nanostructures with Specific Trigger Sequences.”  Chemical Communications 49 (4) 397-399 (2012)  DOI: 10.1039/C2CC36878A

K. Hsieh, A.S. Patterson, B.S. Ferguson, K.W. Plaxco, and H.T. Soh.  “Rapid, Sensitive, and Quantitative Detection of Pathogenic DNA at the Point of Care via Microfluidic Electrochemical Quantitative Loop-Mediated Isothermal Amplification (MEQ-LAMP).”   Angewandte Chemie International Edition 51 (20) 4896–4900 (2012)  DOI: 10.1002/anie.201109115

C.A. Olson, J. Nie, J. Diep, I. Al-Shyoukh, T.T. Takahashi, L.Q. Al-Mawsawi, J.M. Bolin, A.L. Elwell, S. Swanson, R. Stewart, J.A. Thomson, H.T. Soh, R.W. Roberts, and R. Sun.  “Single Round, Multiplexed Antibody Mimetic Design via mRNA Display.”  Angewandte Chemie International Edition 51 (50) 12449–12453 (2012)  DOI: 10.1002/anie.201207005

K. Ahmad, Y. Xiao, and H.T. Soh.  “Selection is more intelligent than design: improving the affinity of a bivalent ligand through directed evolution.”  Nucleic Acids Research 40 (22) 1-7 (2012)  DOI: 10.1093/nar/gks899


B.S. Ferguson, S.F. Buchsbaum, T-T. Wu, K. Hsieh, Y. Xiao, R. Su, and H.T. Soh.  “Genetic Analysis of H1N1 Influenza Virus from Throat Swab Samples in a Microfluidic System for Point-of-Care Diagnostics.”  Journal of the American Chemical Society 133 (23) 9129-9135 (2011)  DOI: 10.1021/ja203981w

I. Olmsted, Y. Xiao, M. Cho, A. Csordas, J. Sheehan, J. Meiler, H.T. Soh, and D. Bornhop.  “Measurement of Aptamer-Protein Interactions with Back-Scattering Interferometry.”  Analytical Chemistry 83 (23) 8867-8870 (2011)  DOI: 10.1021/ac202823m

J. Wang, Y. Liu, T. Teesalu, K.N. Sugahara, V.R. Kotamraju, J.D. Adams, B.S. Ferguson, Q. Gong, S-S. Oh, A.T. Csordas, M. Cho, E. Ruoslahti, Y. Xiao, and H.T. Soh.  “Selection of Phage-Displayed Peptides on Live Adherent Cells in Microfluidic Channels.”  Proceedings of the National Academy of Sciences 108 (17) 6909-6914 (2011)  DOI: 10.1073/pnas.1014753108

K.M. Ahmad, S-S. Oh, S. Kim, F.M. McClellen, Y. Xiao, and H.T. Soh.  “Probing the Limits of Aptamer Affinity with a Microfluidic SELEX Platform.”  PLoS One 6 (11) e27051 (2011)  DOI: 10.1371/journal.pone.0027051

D.R. Hayhurst, K.T. Kedward, H.T. Soh, and K.L. Turner.  “Innovation-Led Multi-Disciplinary Undergraduate Design Teaching.”  Journal of Engineering Design 23 (3) 159-184 (2011)  DOI: 10.1080/09544828.2010.544248

X. Zuo, F. Xia, A. Patterson, H.T. Soh, Y. Xiao, and K.W. Plaxco.  “Two step, PCR-free Telomerase Detection using Exonuclease III Aided Target Recycling.”  ChemBioChem 12 (18) 2745-2447 (2011)  DOI: 10.1002/cbic.201100592

K.W. Plaxco and H.T. Soh.  “Switch-based Biosensors: A New Approach Towards Real-time, In Vivo Molecular Detection.”  Trends in Biotechnology 29 (1) 1-5 (2011)  DOI: 10.1016/j.tibtech.2010.10.005

K. Hsieh, R.J. White, B.S. Ferguson, K.W. Plaxco, Y. Xia, and H.T. Soh.  “Polarity-Switching Electrochemical Sensor for Specific Detection of Single-Nucleotide Mismatches.”  Angewandte Chemie International Edition 50 (47) 11176–11180 (2011)  DOI: 10.1002/anie.201103482

S-S. Oh, K. Ahmad, M. Cho, S. Kim, Y. Xiao, and H.T. Soh.  “Improving Aptamer Selection Efficiency through Volume Dilution, Magnetic Concentration, and Continuous Washing in Microfluidic Channels.”  Analytical Chemistry 83 (17) 6883-6889 (2011)  DOI: 10.1021/ac201269f

R. White, H. Kallewaard, K. Hsieh, A. Patterson, J. Kasehagen, K. Cash, T. Uzawa, H.T. Soh, and K.W. Plaxco.  “A Wash-free, Electrochemical Platform for the Quantitative, Multiplexed Detection of Specific Antibodies.”  Analytical Chemistry 84 (2) 1098-1103 (2011)  DOI: 10.1021/ac202757c

C.A. Olson, J.D. Adams, T.T. Takahashi, H. Qi, S.M. Howell, T-T Wu, R.W. Roberts, R. Sun, and H.T. Soh.  “Rapid mRNA Display Selection of an IL-6 Inhibitor Using Continuous Flow Magnetic Separation.”  Angewandte Chemie International Edition 50 (36) 8295-8298 (2011)  DOI: 10.1002/anie.201101149

J. Kogot, Y. Zhang, S. Moore, P. Pagano, D. Stratis-Cullum, D. Chang-Yen, M. Turewicz, P. Pellegrino, A. de Fusco, H.T. Soh, and N. Stagliano.  “Screening of Peptide Libraries against Protective Antigen of Bacillus Anthracis in a Disposable Microfluidic Cartridge.”  PLoS One 6 (11) 1-9 (2011)  DOI: 10.1371/journal.pone.0026925.g007


M. Cho, Y. Xiao, J. Nie, R. Stewart, A. Csordas, S-S. Oh, J. Thomson, and H.T. Soh.  “Quantitative Selection of DNA Aptamers through Microfluidic Selection and High Throughput Sequencing.”  Proceedings of the National Academy of Sciences 107 (35) 15373-15378 (2010)  DOI: 10.1073/pnas.1009331107

S-S. Oh, K. Plakos, X. Lou, Y. Xiao, and H.T. Soh.  “In Vitro Selection of Structure-Switching, Self-Reporting Aptamers.”  Proceedings of the National Academy of Sciences 107 (32) 14053-14058 (2010)  DOI: 10.1073/pnas.1009172107

Y.K. Jung, T.W. Kim, H.G. Park, and H.T. Soh.  “Specific Colorimetric Detection of Proteins using Bidentate Aptamer-Conjugated Polydiacetylene (PDA) Liposomes.”  Advanced Functional Materials 20 (18) 3092-3097 (2010)  DOI: 10.1002/adfm.201001008

K. Hsieh, Y. Xiao, and H.T. Soh.  “Electrochemical DNA Detection via Exonuclease and Target-catalyzed Transformation of Surface-Bound Probe.”  Langmuir 26 (12) 10392-10396 (2010)  DOI: 10.1021/la100227s

P. Thévoz, J.D. Adams, H. Shea, H. Bruus, and H.T. Soh.  “Acoustophoretic Synchronization of Mammalian Cells in Microchannels.”  Analytical Chemistry 82 (7) 3094-3098 (2010)  DOI: 10.1021/ac100357u

Y. Xiao, K. Dane, T. Uzawa, A. Csordas, J. Qian, H.T. Soh, P. Daugherty, E. Lagally, A. Heeger, and K. Plaxco.  “Detection of Telomerase Activity in High Concentration of Cell Lysates Using Primer-Modified Gold Nanoparticles.”  Journal of the American Chemical Society 132 (43) 15299-15307 (2010)  DOI: 10.1021/ja106513f

A. Csordas, A. E. Gerdon, J. D. Adams, J. Qian, S. S. Oh, Y. Xiao, and H. T. Soh.  “Detection of Proteins in Serum via Micromagnetic Aptamer PCR (MAP) Technology.”  Angewandte Chemie International Edition 49 (2) 355-358 (2010)  DOI: 10.1002/anie.200904846

J.D. Adams and H.T. Soh.  “Tunable Acoustophoretic Band-Pass Particle Sorter.”  Applied Physics Letters 97 (6) 064103 (2010)  DOI: 10.1063/1.3467259


Y. Xiao, K.J.I. Plakos, X. Lou, R.J. White, J. Qian, K.W. Plaxco, and H.T. Soh.  “Fluorescence Detection of Single-Nucleotide Polymorphisms with a, Self-Complementary, Triple-Stem DNA Probe.”  Angewandte Chemie International Edition 48 (24) 4354-4358 (2009)  DOI: 10.1002/anie.200900369

Y. Xiao, X.H. Lou, T. Uzawa, K.J.I. Plakos, K.W. Plaxco, and H.T. Soh.  “An Electrochemical Sensor for Single Nucleotide Polymorphism Detection in Serum Based on a Triple-Stem DNA Probe.”  Journal of the American Chemical Society 131 (42) 15311-15316 (2009)  DOI: 10.1021/ja905068s

Y. Liu, J.D. Adams, K. Turner, F.V. Cochran, S. Gambhir, and H.T. Soh.  “Controlling the Selection Stringency of Phage Display Using a Microfluidic Device.”  Lab on a Chip 9 1033-1036 (2009)  DOI: 10.1039/B820985E

B.S. Ferguson, S. Buchsbaum, J. Swensen, K. Hsieh, X.H. Lou, and H.T. Soh.  “Integrated Microfluidic Electrochemical DNA Sensor.”  Analytical Chemistry 81 (15) 503-6508 (2009)  DOI: 10.1021/ac900923e

J. Swensen, Y. Xiao, B.S. Ferguson, A. Lubin, R. Lai, A.J. Heeger, K.W. Plaxco, and H.T. Soh.  “Continuous, Real-Time Monitoring of Cocaine in Undiluted Blood Serum via a Microfluidic Electrochemical Aptamer-Based Sensor.”  Journal of the American Chemical Society 131 (12) 4262-4266 (2009)  DOI: 10.1021/ja806531z

J.D. Adams and H.T. Soh.  “Perspectives on Utilizing Unique Features of Microfluidics Technology for Particle and Cell Sorting.”  Journal of the Association for Laboratory Automation 14 (6) 331-340 (2009)  DOI: 10.1016/j.jala.2009.06.003

X.H. Lou, J. Qian, Y. Xiao, L. Viel, A.E. Gerdon, E.T. Lagally, P. Atzberger, T.M. Tarasow, A.J. Heeger, and H.T. Soh.   “Micromagnetic Selection of Aptamers in Microfluididc Channels.”  Proceedings of the National Academy of Sciences 106 (9) 2989-2994 (2009) DOI: 10.1016/j.jala.2009.06.003

S-S. Oh, J. Qian, X.H. Lou, Y. Zhang, Y. Xiao, and H.T. Soh.  “Generation of Highly Specific Aptamers via Micromagnetic Selection.”  Analytical Chemistry 81 (13) 5490-5495 (2009)  DOI: 10.1021/ac900759k

A.E. Gerdon, S-S. Oh, K. Hsieh, Y. Ke, H. Yan, and H.T. Soh.  “Controlled Delivery of DNA Origami on Patterned Surfaces.”  Small 5 (17) 1942-1946 (2009)  DOI: 10.1002/smll.200900442

U. Kim and H.T. Soh.  “Simultaneous Sorting of Multiple Bacterial Targets Using Integrated Dielectrophoretic-Magnetic Activated Cell Sorter.”  Lab on a Chip 9 2313-2318 (2009)  DOI: 10.1039/B903950C

J. D. Adams, P. Thévoz, H. Shea, H. Bruus, and H. T. Soh.  “Integrated Acoustic and Magnetic Separation in Microfluidic Channels.”  Applied Physics Letters 95 (25) 254103 (2009)  DOI: 10.1063/1.3275577


E. Pavlovic, R.Y. Lai, T-T Wu, B.S. Ferguson, R. Sun, K.W. Plaxco, and H.T. Soh.  “Microfluidic Device Architecture for Electrochemical Patterning and Detection of Multiple DNA Sequences.”  Langmuir 24 (3) 1102-1107 (2008)  DOI: 10.1021/la702681c

S. Pennathur, C. Meinhart, and H.T. Soh.  “How to Exploit the Features of Microfluidics.”  Lab on a Chip 8 20-22 (2008)  DOI: 10.1039/B717986N

J.D. Adams, U. Kim, and H.T. Soh.  “Multitarget magnetic activated cell sorter.”  Proceedings of the National Academy of Sciences 105 (47) 18165-18170 (2008)  DOI: 10.1073/pnas.0809795105

U. Kim, J. Qian, S.A. Kenrick, P.S. Daugherty, and H.T. Soh.  “Multitarget Dielectrophoresis Activated Cell Sorter.”  Analytical Chemistry 80 (22) 8656-8661 (2008)  DOI: 10.1021/ac8015938

M.S. Pommer, Y. Zhang, N. Keerthi, D. Chen, J.A. Thomson, C. Meinhart, and H.T. Soh.  “Dielectrophoretic Separation of Platelets from Diluted Whole Blood in Microfluidic Channels.”  Electrophoresis 29 (6) 1213-1218 (2008)  DOI: 10.1002/elps.200700607


U. Kim, C-W Shu, K.Y. Dane, P.S. Daugherty, J.Y. Wang, and H.T. Soh.  “Selection of Mammalian Cells According to Cell-Cycle Phase Using Dielectrophoresis.”  Proceedings of the National Academy of Sciences 104 (52) 20708-20712 (2007)  DOI: 10.1073/pnas.0708760104

P.H. Bessette, X. Hu, H.T. Soh, and P.S. Daugherty.  “Microfluidic Library Screening for Mapping Antibody Epitopes.”  Analytical Chemistry 79 (5) 2174-2178 (2007)  DOI: 10.1021/ac0616916


R. Lai, S-H Lee, H.T. Soh, K.W. Plaxco, and A.J. Heeger.  “Differential Labeling of Closely-Spaced Biosensor Electrodes via Benign Oxidative Desorption.”  Langmuir 22 (4) 1932-1936 (2006)  DOI: 10.1021/la052132h

S-H. Oh, S-H Lee, S.A. Kenrick, P.S. Daugherty, and H.T. Soh.  “Microfluidic Protein Detection through Genetically Engineered Bacterial Cells.”  Journal of Proteome Research 5 (22) 3433-3437 (2006)  DOI: 10.1021/pr060193a

R.Y. Lai, E.T. Lagally, S-H. Lee, H.T. Soh, K.W. Plaxco, and A.J. Heeger.  “Rapid Sequence-Specific Detection of Unpurified PCR Amplicons via a Reusable, Electronic Sensor.”  Proceedings of the National Academy of Sciences 103 (11) 4017-4021 (2006)  DOI: 10.1073/pnas.0511325103


E.T. Lagally and H.T. Soh.  “Integrated Genetic Analysis Microsystems.”  Critical Reviews in Solid State and Material Sciences 30 (4) 208-233 (2005)  DOI: 10.1080/10408430500332149

D.K. Wood, S-H Oh, S-H Lee, H.T. Soh, and A.N. Cleland.  “High Bandwidth Radiofrequency Coulter Counter.”  Applied Physics Letters 87 (18) 184106 (2005)  DOI: 10.1063/1.2125111

X. Hu, P. H. Bessette, J. Qian, C. D. Meinhart, P. S. Daugherty, and H. T. Soh.  “Marker Specific Sorting of Rare Cells Using Dielectrophoresis.”  Proceedings of the National Academy of Sciences 102 (44) 15757-15761 (2005)  DOI: 10.1073/pnas.0507719102

E. T. Lagally, S-H Lee, and H. T. Soh.  “Integrated Microsystem for Dielectrophoretic Cell Concentration and Genetic Detection.”  Lab on a Chip (5) 1053-1058 (2005)  DOI: 10.1039/B505915A 


D. S. Greywall, P. A. Busch, F. Pardo, D. W. Carr, G. Bogart, and H. T. Soh.  “Crystalline Silicon Tilting Mirrors for Optical Cross Connect Switches.”  Journal of Microelectromechanical Systems 12 708-712 (2003)  DOI: 10.1109/JMEMS.2003.818067

D.S. Greywall, C-S Pai, S-H Oh, C P. Chang, D.M. Marom, P.A. Busch, R.A. Cirelli, J.A. Taylor, F.P. Klemens, T.W. Sorsch, J.E. Bower, W.Y. Lai, and H.T. Soh.  “Monolithic Fringe-Field-Activated Crystalline Silicon Tilting-Mirror Devices.”  Journal of Microelectromechanical Systems 12 (5) 702-707 (2003)  DOI: 10.1109/JMEMS.2003.818068


H. T. Soh, K. Wilder-Guarini, and C. F. Quate  “Scanning Probe Lithography” (2001)


E.M. Chow, H.T. Soh, H.C. Lee, J.D. Adams, S.C. Minne, G. Yaralioglu, A. Atalar, C.F. Quate, and T.W. Kenny.  “Integration of Through-Wafer Interconnects with a Two-Dimensional Cantilever Array.”  Sensors & Actuators A-Physical 83 (1-3) 118-123 (2000)  DOI: 10.1016/S0924-4247(99)00381-7

X.N. Qi, C. Yue, T. Arnborg, H.T. Soh, H. Sakai, Z.P. Yu, and R.W. Dutton.  “A fast 3-D modeling approach to electrical parameters extraction of bonding wires for RF circuits.”  IEEE Transactions on Advanced Packaging 23 (3) 480 (2000)  DOI: 10.1109/6040.861564


H.T. Soh, C.P. Yue, A.M. McCarthy, C. Ryu, T.H. Lee, S.S. Wong, and C.F. Quate.  “Ultra-Low resistance, Through-Wafer Via (TWV) Technology and Its Applications in Three Dimensional Structures on Silicon.”  Japanese Journal of Applied Physics 38 2393 (1999)  DOI: 10.1143/JJAP.38.2393

H.T. Soh, A.F. Morpurgo, J. Kong, C.M. Marcus, C.F. Quate, and H. Dai.  “Integrated nanotube circuits: Controlled growth and ohmic contacting of single walled carbon nanotubes.”  Applied Physics Letters 75 (5) 627 (1999)  DOI: 10.1063/1.124462

J. Kong, C. Zhou, A. Morpurgo, H.T. Soh, C.F. Quate, C. Marcus, and H. Dai.  “Synthesis, integration, and electrical properties of individual single-walled carbon nanotubes.”  Applied Physics A 69 (3) 305 (1999)  DOI: 10.1007/s003390051005

K. Wilder, H.T. Soh, A. Atalar, and C F. Quate.  “Nanometer-scale patterning and individual current-controlled lithography using multiple scanning probes.”  Review of Scientific Instruments 70 (6) 2822 (1999)  DOI: 10.1063/1.1149802


H.T. Soh, J. Kong, A.M. Cassell, C.F. Quate, and H. Dai.  “Synthesis of Individual Single-Walled Carbon Nanotubes on Patterned Silicon Wafers.”  Nature 395 878-881 (1998)DOI: 10.1038/27632

I. Ladabaum, X.C. Jin, H.T. Soh, A. Atalar, and B.T. Khuri-Yakub.  “Surface micromachined capacitive ultrasonic transducers.”  IEEE Transactions on Ultrasonics, Ferroelectronics, and Frequency Control 45 (3) 678 (1998)  DOI: 10.1109/58.677612


K. Wilder, H T. Soh, A. Atalar, and C.F. Quate.  “The hybrid atomic force/scanning tunneling lithography system.”  Journal of Vacuum Science and Technology B 15 (5) 1811 (1997)  DOI: 10.1116/1.589530


H.T. Soh, I. Ladabaum, A. Atalar, and C.F. Quate.  “Silicon micromachined ultrasonic immersion transducers.”  Applied Physics Letters 69 (24) 3674 (1996)  DOI: 10.1063/1.117185


S.W. Park, H.T. Soh, C.F. Quate, and S-I Park.  “Nanometer scale lithography at high scanning speeds with the atomic force microscope using spin on glass.”  Applied Physics Letters 67 (16) 2415 (1995)  DOI: 10.1063/1.114565

S.C. Minne, H.T. Soh, Ph. Flueckiger, and C.F. Quate.  “Fabrication of 0.1μm metal oxide semiconductor field-effect transistors with the atomic force microscope.”  Applied Physics Letters 66 (6) 703 (1995)  DOI: 10.1063/1.114105

S.C. Minne, Ph. Flueckiger, H.T. Soh, and C.F. Quate. “Atomic force microscope lithography using amorphous silicon as a resist and advances in parallel operation.”  Journal of Vacuum Science and Technology B 13 (3) 1380 (1995)  DOI: 10.1116/1.587857